Computers in Cardiology abstract deadline extended (May 3, 2003, midnight)
Participants in the PhysioNet/Computers in Cardiology Challenge 2003 have an extra week to submit abstracts describing their work, since the conference has extended the abstract deadline to Thursday, 8 May.
PhysioNet/CinC Challenge 2003 (March 6, 2003, midnight)
The fourth annual PhysioNet/Computers in Cardiology Challenge has begun. Is it possible to tell the difference between transient ST changes in the ECG that are due to myocardial ischemia, and those that are not? We invite you to participate in this challenge, making use of the recently completed Long-Term ST Database to study this provocative question.
When using this resource, please cite the following publications:
For the fourth annual PhysioNet/Computers in Cardiology Challenge, we propose a provocative question of considerable clinical interest:
Is it possible to tell the difference between transient ST changes in the ECG that are due to myocardial ischemia, and those that are not?
For many years, a simple answer (“no”) was considered to be the final word on this question. Myocardial ischemia results from insufficient oxygen delivery to the myocardium. To diagnose myocardial ischemia definitively, it is necessary to document that blood flow, blood oxygen saturation, or both have been compromised to an extent that the oxygen demands of the myocardium are not satisfied. These diagnostic criteria are typically established by imaging the coronary arteries. Since the ECG does not contain direct information about blood flow or oxygen saturation, it cannot be used to diagnose ischemia.
It may be possible, however, to establish inferential associations between specific features of the ECG and myocardial ischemia. One such association, between transient ischemia and changes in the ST segment of the ECG, is very widely known, and is understood to be highly sensitive, but not specific. It has long been known that repolarization of ischemic myocardial regions is abnormal, that these abnormalities are visible in the ST segment, and that they can be quantified by measuring the deviation of certain portions of the ST segment from baseline measurements. It is also known that deviations in these ST segment measurements can result from a wide variety of other causes, including changes in heart rate, conduction pattern, position of the subject, and noise in the ECG. As a result, observations of transient ST changes are considered suggestive of ischemia but are not sufficient for a definitive diagnosis, absent conclusive evidence from imaging studies.
Even in subjects who are known to have myocardial ischemia, ST changes are not considered a basis for definitive diagnosis of individual episodes of ischemia. In a subject with an old myocardial infarction, for example, the infarct may result in an ST segment with a persistent abnormal pattern (in the frame of reference of the heart). This fixed pattern appears to change with the subject’s body position (upright, supine, etc.) because of movement of the ECG elecrodes relative to the heart. Thus many of those subjects who are most likely to experience ischemia are also among those most likely to have non-ischemic ST changes.
Therapeutic intervention to reduce or eliminate transient ischemic episodes can make a significant difference in quality of life for affected subjects, and may reduce mortality and morbidity in this population. Assessment of the effectiveness of therapy is substantially hindered by the lack of a reliable way of identifying ischemic episodes during activities of daily living, in which imaging studies are not possible. If it were possible to distinguish between ischemic and non-ischemic ST changes in ambulatory ECG recordings made during subjects’ normal activities, the benefits would be immediate and substantial, in terms of a reduction in the time needed to determine and validate effective therapies, hence in the risk and pain experienced by the affected subjects.
This year’s challenge topic encourages participants to develop novel approaches to analysis of transient ST changes using the recently-completed Long-Term ST Database, a meticulously annotated collection of 86 recordings of 2- and 3-lead long-term (20-24 hour) ECGs. Each ST change that meets criteria of clinical significance has been carefully studied by a team of expert annotators, who have drawn upon all available evidence to determine which of these events are consistent with a diagnosis of myocardial ischemia, and which are consistent with other causes. Half of these 86 recordings have been contributed to PhysioNet and are available to participants as a learning set. The remaining recordings form the test set.
Participants are challenged to design and implement algorithms that can closely mimic the decisions made by the expert annotators, classifying the ST changes (events) in the test set as ischemic or non-ischemic. The algorithms are not required to detect the events, but only to classify each given event as ischemic, non-ischemic, or indeterminate.
As noted above, the data used for this challenge come from the Long-Term ST Database. The learning set consists of the 43 records available from PhysioNet. Participants should train their algorithms using these records. The test set consists of the other 43 records.
To enter the challenge, participants will submit their classifiers by email to PhysioNet, where the entries will be compiled and used to classify the ST events in the test set. Each algorithm will receive a score determined by the number of correctly classified events, less the number of incorrectly classified events (those left unclassified will not affect the score). Scores will be returned to participants by email, and high scores will be posted on PhysioNet and updated throughout the challenge period. Participants may revise and resubmit their entries until the challenge deadline of noon GMT on Friday, 12 September 2003.
All participants are encouraged to submit an abstract to Computers in Cardiology 2003 describing their approach to the challenge. (When submitting your abstract, choose the topic “Computers in Cardiology Challenge”.) Abstracts are due on Thursday, 1 May 2003 (note: this deadline has been extended to Thursday, 8 May 2003); details are available on the Computers in Cardiology web site. If your abstract is accepted, you will be expected to prepare a four-page manuscript (due on Tuesday, 23 September 2003) for publication in the conference proceedings, and you will have the opportunity to discuss your work at the conference. To be eligible for an award, you must submit an abstract and attend the conference.
The eligible participant whose algorithm receives the highest score will receive an award of US$1000, to be presented at Computers in Cardiology 2003 (in Thessaloniki, Greece, 21-24 September 2003). A selection of the classifiers will be posted on PhysioNet following the conference.
Use the learning set to develop criteria for classifying the ST events. We recommend that you begin by copying a set of input files for one record of the learning set into an empty local directory. The files that your program will be permitted to read are:
.hea) and signal (
.dat) files, permitting access to the digitized ECG signals;
.atr) and ST measurement (
.16a) files, providing QRS times of occurrence for each beat, and continuously updated ST-segment measurements based on 16-beat moving averages;
.stffile, containing the ST level, reference, and deviation for each input signal, at two-second intervals throughout the recording
.kltfile (decompressed from the
.klt.zipfiles available on-line), containing time series of ST and QRS principal components
In addition, your program will need to have a copy of the
.epi file for
the record. These text files have been prepared for this Challenge from
.stb reference annotation files of the Long-Term ST Database; they
contain the times of significant ST changes, but not the classifications
of those events. Your program is not expected to detect the events, but
to classify them, so this file is available to substitute for an ST
Your program may use any or all of these files as a basis for
classifying the ST events. In principle, all of the other files are
derivable from the signal (
.dat) file, but you are not expected to do
so! The other files are provided for use as shortcuts to a solution of
the challenge problem; in a clinical application, it would be necessary
to integrate the code needed to detect and classify the QRS complexes,
measure the ST deviations, and detect the ST events.
For example, to work with record s30701 of the learning set, download
The last of these files, s30701.epi, is derived from s30701.stb; it contains:
1 40125 2 ? 2 40129 1 ? 3 64361 0 ? 4 64361 1 ? 5 76639 2 ? 6 76647 1 ? 7 77171 2 ? 8 77551 2 ? 9 79967 1 ? 10 79975 2 ?
Each line contains information about one event. From left to right, the
columns contain an event ID number, the time of the event (the elapsed
time from the beginning of the record, in seconds), the signal number
(0, 1, or 2) of the affected ECG signal, and the classification of the
? means ‘indeterminate’.
At the end of each run, your program must have copied the
.epi file into
.epo file, replacing the
? placeholders with its classifications.
I to mark ischemic and
N to mark non-ischemic events; you
may leave indeterminate events marked with
?. For example, the
correct classifications for record
1 40125 2 N 2 40129 1 N 3 64361 0 N 4 64361 1 N 5 76639 2 I 6 76647 1 I 7 77171 2 I 8 77551 2 I 9 79967 1 I 10 79975 2 I
Thus, the first four ST changes in this example are non-ischemic (in
s30701.sta, the expert annotators have marked them as due to axis
shift), and the remaining six are consistent with ischemia.
Your program’s score will be determined by comparing the output .epo
files with a set of reference
.epr files. The
.epr files are identical
.epi files, except that the classification of each ST event,
based on the
.stb annotations, is included in place of the
markers. A point is added to your score for each match (
a point is deducted for each mismatch (
I). ST events left
?) do not affect your score. (A set of
.epr files for
the learning set is available for use while you are developing your
.epr files for the test set are not available; don’t
The number of events per record varies considerably, from fewer than ten
to several hundred. To avoid giving undue weight in the score to the
handful of records that have a majority of the events, the
for the test set contain no more than 20 events each (which have been
chosen at random from all of the events in those records with more than
20 annotated events). Only these events will be used as the basis for
scoring the entries; the others will not be counted. The same set of
.epr files will be used to score all entries.
Begin by downloading
stclass.c (to be used unmodified) and
(to be used as a template for your entry).
stclass.c) to record your classifications.
?). You can invoke label to mark any of the events at any time (so, for example, you can invoke label from your analyze function if you wish to label the events one at a time, or you can invoke label once per event from your finalize function after accumulating information about all of the events. Your algorithm can relabel any event by invoking label a second (or third, ...) time with the same event ID. Any events that you do not label are marked as
You may, if necessary:
If you create temporary files, do so within the current directory only, and use file names beginning with temp. Any files created will be removed between runs (you cannot save information from one run to use in another).
All code will be reviewed before being compiled or run. Please keep your code neat. If we can’t figure out what your program does, we won’t run it!
All code must compile cleanly using:
gcc -Wall stclass.c -lm -lwfdb
There must be no errors or warnings of any kind. See the WFDB Software Package for information about the WFDB library.
If your program does not make use of the
it can be compiled without the WFDB library using:
gcc -Wall -DNOWFDB stclass.c -lm
Your program must run to completion within a reasonable time. A reasonable time is 5 minutes or less for a 24-hour record running on a 1 GHz Athlon under Linux; we will not disqualify programs that slightly exceed this limit.
Test your entry before submitting it. Don’t forget to include your
name, affiliation, and email address in the comment block at the top
analyze.c. Once you are ready, send a copy of your version of
analyze.c (source only; do not send binaries) via email to
with a subject line of
analyze.c. Please send
analyze.c as plain
text, not as HTML or as a word-processor formatted attachment.
Once your entry has been given a number, we will run it on the test set and you will receive a score by return email. The top scores will be posted on PhysioNet and will be updated as new entries arrive. You may revise and resubmit your entry if you wish; note, however, that the challenge organizers will give priority to new participants, so that there may be a delay in receiving scores for revised entries.
We will continue to accept entries until noon GMT on Friday, 12 September 2003. All valid entries submitted before this deadline will be scored.
At Computers in Cardiology 2003 (in Thessaloniki, Greece, 21-24 September 2003), a prize of US$1000 will be awarded to the top-scoring eligible participant. Immediately following the conference, a selection of the programs entered will be posted with full credit to their authors, and they will be made freely available under the GPL (or another open source license of the author’s choice).
Members and affiliates of our research groups at MIT, Boston University, Harvard Medical School, Beth Israel Deaconess Medical Center, and McGill University are not eligible for awards, although all are welcome to participate.
To qualify for an award, a participant must do all of the following:
All deadlines are at noon GMT unless otherwise indicated. Late submissions will not be accepted.
Where are the
These files are not part of the Long-Term ST Database; they were created
specifically for this challenge, and they can be found in the Files
section below (in the
Are the classifiers allowed to read the clinical notes included in the
Parsing those notes to understand how to classify individual episodes would be an impressive accomplishment ... but that is not the intent of the challenge! The .hea files made available to submitted classifiers for the test set will be stripped of these notes.
Why don’t you have a challenge about ...?
Each year, we receive many suggestions for challenge topics. We encourage you to contact us with further suggestions.
A team of researchers from the University of Newcastle upon Tyne and Freeman Hospital won the 2003 PhysioNet Computers in Cardiology Challenge for their work on computer detection of ischaemia from the electrocardiogram (ECG).
Ischaemia, when the heart muscle is starved of oxygen, is clinically very important and can indicate heart disease, such as coronary artery disease. Automated computer detection of the condition in ambulatory ECG recordings is very difficult because many of the daily activities undertaken by patients give characteristics on the ECG similar to those of ischaemia.
The Challenge, organised by Massachusetts Institute of Technology, PhysioNet, and Computers in Cardiology, is an annual event in which researchers from around the world compete to solve a specific research question.
The team from Newcastle (Philip Langley, Emma Bowers, Joanne Wild, Michael Drinnan, John Allen, Andrew Sims, Nigel Brown and Alan Murray) are members of the Cardiovascular Physics and Engineering Research Group from the Department of Medical Physics. The paper was presented by Philip and certificates and prize money were handed to representatives of the team at the Computers in Cardiology conference held in Thessaloniki, Greece.
These papers were presented at Computers in Cardiology 2003. Please cite this publication when referencing any of these papers. Links below are to copies of these papers on the CinC web site.
Anyone can access the files, as long as they conform to the terms of the specified license.
Access the data using the Google Cloud command line tools (please refer to the gsutil documentation for guidance):
gsutil -m -u YOUR_PROJECT_ID cp -r gs://challenge-2003-1.0.0.physionet.org DESTINATION
Download the files using your terminal:
wget -r -N -c -np https://physionet.org/files/challenge-2003/1.0.0/
Supported by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under NIH grant number R01EB030362.